Dendritic cell-specific disruption of TGFβ receptor II leads to altered regulatory T-cell phenotype and spontaneous multi-organ autoimmunity

In vitrodata and transgenic mouse models suggest a role for TGFβ signaling in dendritic cells (DC) to prevent autoimmunity primarily through maintenance of DCs in their immature and tolerogenic state characterized by low expression of MHCII and co-stimulatory molecules, and increased expression of i...

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Main Authors:	Ramalingam, Rajalakshmy, Larmonier, Claire B., Thurston, Robert D., Midura-Kiela, Monica T., Zheng, Song Guo, Ghishan, Fayez K., Kiela, Pawel R.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2012
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3466393/ https://ncbi.nlm.nih.gov/pubmed/22972928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201029
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Dendritic cell-specific disruption of TGFβ receptor II leads to altered regulatory T-cell phenotype and spontaneous multi-organ autoimmunity

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