Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

We have investigated the contribution of individual phosphoinositide 3-kinase (PI3K) Class I isoforms to the regulation of neutrophil survival using (i) a panel of commercially available small molecule isoform-selective PI3K Class I inhibitors, (ii) novel inhibitors, which target single or multiple...

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Bibliographic Details
Main Authors: Juss, Jatinder K., Hayhoe, Richard P., Owen, Charles E., Bruce, Ian, Walmsley, Sarah R., Cowburn, Andrew S., Kulkarni, Suhasini, Boyle, Keith B., Stephens, Len, Hawkins, Phillip T., Chilvers, Edwin R., Condliffe, Alison M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454369/
https://ncbi.nlm.nih.gov/pubmed/23029326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045933
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