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Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1

Tumor cycling hypoxia is now a well-recognized phenomenon in animal and human solid tumors. However, how tumor cycling hypoxia impacts chemotherapy is unclear. In the present study, we explored the impact and the mechanism of cycling hypoxia on tumor microenvironment-mediated chemoresistance. Hoechs...

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Detalhes bibliográficos
Main Authors: Chou, Chii-Wen, Wang, Chi-Chung, Wu, Chung-Pu, Lin, Yu-Jung, Lee, Yu-Chun, Cheng, Ya-Wen, Hsieh, Chia-Hung
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3452342/
https://ncbi.nlm.nih.gov/pubmed/22946104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nos195
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