Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

Using a monoclonal antibody to the human epidermal growth factor (EGF) receptor (EGF-R1), we have followed the metabolism of the receptor and the pathway of its internalization in KB cells after the addition of EGF. Measurement of surface binding of 125I-labeled EGF showed that about 80% of EGF bind...

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Détails bibliographiques
Auteurs principaux: Beguinot, L, Lyall, R M, Willingham, M C, Pastan, I
Format: Artigo
Langue:Inglês
Publié: 1984
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC345064/
https://ncbi.nlm.nih.gov/pubmed/6326124
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