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Building high affinity human antibodies by altering the glycosylation on the light chain variable region in N-acetylglucosamine-supplemented hybridoma cultures

We attempted to improve antibody affinity by varying glycosylation on the light chain variable region. The human hybridoma line HB4C5 produces an antibody reactive to lung adenocarcinoma, which possess a N-glycosylated carbohydrate chain on the light chain hypervariable region. It has been shown tha...

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Detaylı Bibliyografya
Asıl Yazarlar: Tachibana, Hirofumi, Kim, Ji-youn, Shirahata, Sanetaka
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Kluwer Academic Publishers 1997
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449873/
https://ncbi.nlm.nih.gov/pubmed/22358531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1007980032042
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