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The 48-base-long primordial building block of immunoglobulin light-chain variable regions is complementary to the primordial building block of heavy-chain variable regions.

The ancestral gene for immunoglobulin light-chain variable regions (Ig VLs) of the kappa as well as the lambda class apparently arose from about 12 tandem repeats of the 48-base-long primordial building block sequence TCT-TGC-GCA-GTA-AGT-CCA-CTC-CAG-GTC-ATA-TCC-AGT-CAG-GCT-GCT-GAA. Even today, amino...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ohno, S, Matsunaga, T
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1982
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC346188/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6808518/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.7.2338
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