The 48-base-long primordial building block of immunoglobulin light-chain variable regions is complementary to the primordial building block of heavy-chain variable regions.

The ancestral gene for immunoglobulin light-chain variable regions (Ig VLs) of the kappa as well as the lambda class apparently arose from about 12 tandem repeats of the 48-base-long primordial building block sequence TCT-TGC-GCA-GTA-AGT-CCA-CTC-CAG-GTC-ATA-TCC-AGT-CAG-GCT-GCT-GAA. Even today, amino...

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Bibliographic Details
Main Authors: Ohno, S, Matsunaga, T
Format: Artigo
Language:Inglês
Published: 1982
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC346188/
https://ncbi.nlm.nih.gov/pubmed/6808518
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