An Approach to Further Enhance the Cellular Productivity of Exogenous Protein Hyper-producing Chinese Hamster Ovary (CHO) Cells

The cell line D29, which was easily and rapidly established by the promoter-activated production and glutamine synthetase hybrid system, secreted recombinant human interleukin-6 (hIL-6) at a productivity rate of 39.5 μg 10(−6) cells day(−1), one of the highest reported levels worldwide. The producti...

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Hauptverfasser: Teruya, Kiichiro, Daimon, Yoshihito, Dong, Xiao-Yan, Katakura, Yoshinori, Miura, Takumi, Ichikawa, Akira, Fujiki, Tsukasa, Yamashita, Makiko, Mori, Tetsuya, Ohashi, Hideya, Shirahata, Sanetaka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Kluwer Academic Publishers 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449826/
https://ncbi.nlm.nih.gov/pubmed/19003042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10616-005-3765-4
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