Productivity enhancement of recombinant protein in CHO cells via specific promoter activation by oncogenes

To construct a recombinant protein highly producing cell lines, we have previously developed the Oncogene Activated Production (OAP) system by using BHK-21 cells. Here we verified the availability of the OAP system in CHO cells. We firstly generated ‘primed’ ras amplified CHO cells, ras clone I, by...

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Hlavní autoři: Katakura, Yoshinori, Seto, Perry, Miura, Takumi, Ohashi, Hideya, Teruya, Kiichiro, Shirahata, Sanetaka
Médium: Artigo
Jazyk:Inglês
Vydáno: Kluwer Academic Publishers 1999
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449785/
https://ncbi.nlm.nih.gov/pubmed/19003130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1008048928053
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