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Characterisation of BHK-21 cells engineered to secrete human insulin

Autoimmune destruction of β cells in the pancreas leads to type I, or insulin dependent diabetes mellitus (IDDM), through the loss of endogenous insulin production capacity. This paper describes an attempt to generate ‘artificial’β cells using the fibroblast cell line BHK21. Stable transfectants exp...

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Autors principals: Gammell, Patrick, O'Driscoll, Lorraine, Clynes, Martin
Format: Artigo
Idioma:Inglês
Publicat: Kluwer Academic Publishers 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449758/
https://ncbi.nlm.nih.gov/pubmed/19002958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1024296220592
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