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Non-GMP plasmid production for transient transfection in bioreactors

We describe a generic plasmid purification process for producing DNA for larger-scale transient transfection. Data on plasmid quality with regard to residual protein, endotoxin content and presence of different plasmid forms is given. The effects of contaminants and plasmid forms on expression level...

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Detalhes bibliográficos
Main Authors: Schmid, Georg, Schlaeger, Ernst-Jürgen, Wipf, Beat
Formato: Artigo
Idioma:Inglês
Publicado em: Kluwer Academic Publishers 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449703/
https://ncbi.nlm.nih.gov/pubmed/22358854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1023/A:1013148203049
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