JTV519 (K201) reduces sarcoplasmic reticulum Ca(2+) leak and improves diastolic function in vitro in murine and human non-failing myocardium

BACKGROUND AND PURPOSE: Ca(2+) leak from the sarcoplasmic reticulum (SR) via ryanodine receptors (RyR2s) contributes to cardiomyocyte dysfunction. RyR2 Ca(2+) leak has been related to RyR2 phosphorylation. In these conditions, JTV519 (K201), a 1,4-benzothiazepine derivative and multi-channel blocker...

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Detaylı Bibliyografya
Asıl Yazarlar: Sacherer, M, Sedej, S, Wakuła, P, Wallner, M, Vos, MA, Kockskämper, J, Stiegler, P, Sereinigg, M, von Lewinski, D, Antoons, G, Pieske, BM, Heinzel, FR
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Blackwell Publishing Ltd 2012
Konular:
Research Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449255/
https://ncbi.nlm.nih.gov/pubmed/22509897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01995.x
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