K201 improves aspects of the contractile performance of human failing myocardium via reduction in Ca(2+) leak from the sarcoplasmic reticulum

In heart failure, intracellular Ca(2+) leak from cardiac ryanodine receptors (RyR2s) leads to a loss of Ca(2+) from the sarcoplasmic reticulum (SR) potentially contributing to decreased function. Experimental data suggest that the 1,4-benzothiazepine K201 (JTV-519) may stabilise RyR2s and thereby re...

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Detalles Bibliográficos
Main Authors: Toischer, Karl, Lehnart, Stephan E., Tenderich, Gero, Milting, Hendrik, Körfer, Reiner, Schmitto, Jan D., Schöndube, Friedrich A., Kaneko, Noboru, Loughrey, Christopher M., Smith, Godfrey L., Hasenfuss, Gerd, Seidler, Tim
Formato: Artigo
Idioma:Inglês
Publicado: D. Steinkopff-Verlag 2009
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Original Contribution
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2807967/
https://ncbi.nlm.nih.gov/pubmed/19718543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-009-0057-8
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