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K201 (JTV519) suppresses spontaneous Ca(2+) release and [(3)H]ryanodine binding to RyR2 irrespective of FKBP12.6 association
K201 (JTV519), a benzothiazepine derivative, has been shown to possess anti-arrhythmic and cardioprotective properties, but the mechanism of its action is both complex and controversial. It is believed to stabilize the closed state of the RyR2 (cardiac ryanodine receptor) by increasing its affinity...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1896290/ https://ncbi.nlm.nih.gov/pubmed/17313373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070135 |
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