Targeted inhibition of Src kinase signaling attenuates pancreatic tumorigenesis

Elevated Src expression correlates with malignant potential and metastatic disease in many tumors including pancreas cancer. We sought to characterize the molecular effects of Src kinase inhibition with dasatinib (BMS-354825) a novel, multi-targeted kinase inhibitor that targets Src family kinases,...

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Bibliographic Details
Main Authors: Nagaraj, Nagathihalli S., Smith, J. Joshua, Revetta, Frank, Washington, M. Kay, Merchant, Nipun B.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449211/
https://ncbi.nlm.nih.gov/pubmed/20682659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1212
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