Deletion of Foxp3(+) regulatory T cells in genetically targeted mice supports development of intestinal inflammation

BACKGROUND: Mice lacking Foxp3(+) regulatory T (Treg) cells develop severe tissue inflammation in lung, skin, and liver with premature death, whereas the intestine remains uninflamed. This study aims to demonstrate the importance of Foxp3(+) Treg for the activation of T cells and the development of...

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Main Authors: Boehm, Franziska, Martin, Maria, Kesselring, Rebecca, Schiechl, Gabriela, Geissler, Edward K, Schlitt, Hans-Jürgen, Fichtner-Feigl, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3449180/
https://ncbi.nlm.nih.gov/pubmed/22849659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-12-97
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