Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid.

When arachidonic acid was incubated with homogenates of potato tubers, two isomers of 6-trans-leukotriene B4, epimeric at C-12, were formed in addition to the major product, (5S-hydroperoxy-6-trans-8,11,14-cis-icosatetraenoic acid (5-HPETE). To elucidate the mechanism of biosynthesis of the dihydrox...

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Bibliographic Details
Main Authors: Shimizu, T, Rådmark, O, Samuelsson, B
Format: Artigo
Language:Inglês
Published: 1984
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC344900/
https://ncbi.nlm.nih.gov/pubmed/6322165
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