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Transformation by polyoma virus is drastically reduced by substitution of phenylalanine for tyrosine at residue 315 of middle-sized tumor antigen.

We used an oligonucleotide to introduce an A----T transversion at nucleotide position 1178 in polyoma virus DNA. The single effect of this mutation is to substitute phenylalanine for tyrosine at residue 315 of the middle-sized tumor (mT) protein (antigen). This site was previously identified as a ma...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Carmichael, G, Schaffhausen, B S, Mandel, G, Liang, T J, Benjamin, T L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1984
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344898/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6322163/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.3.679
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