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Rituximab mediates loss of CD19 on B cells in the absence of cell death

OBJECTIVE: To evaluate loss of the B cell specific marker CD19 with addition of rituximab (RTX) to healthy donor blood and to determine the role of complement mediated cytotoxicity in these cells. METHODS: Healthy donor whole blood and peripheral blood mononuclear cells (PBMC) were evaluated for los...

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Main Authors: Jones, Jonathan D., Hamilton, B. JoNell, Rigby, William F. C.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448861/
https://ncbi.nlm.nih.gov/pubmed/22674374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34560
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