Arhgef15 Promotes Retinal Angiogenesis by Mediating VEGF-Induced Cdc42 Activation and Potentiating RhoJ Inactivation in Endothelial Cells

BACKGROUND: Drugs inhibiting vascular endothelial growth factor (VEGF) signaling are globally administered to suppress deregulated angiogenesis in a variety of eye diseases. However, anti-VEGF therapy potentially affects the normal functions of retinal neurons and glias which constitutively express...

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Détails bibliographiques
Auteurs principaux: Kusuhara, Sentaro, Fukushima, Yoko, Fukuhara, Shigetomo, Jakt, Lars Martin, Okada, Mitsuhiro, Shimizu, Yuri, Hata, Masayuki, Nishida, Kohji, Negi, Akira, Hirashima, Masanori, Mochizuki, Naoki, Nishikawa, Shin-Ichi, Uemura, Akiyoshi
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3448698/
https://ncbi.nlm.nih.gov/pubmed/23029280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045858
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