GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K(+) Channel

Infants with congenital hyperinsulinism owing to inactivating mutations in the K(ATP) channel (K(ATP)HI) who are unresponsive to medical therapy will require pancreatectomy to control the hypoglycemia. In preclinical studies, we showed that the GLP-1 receptor antagonist exendin-(9-39) suppresses ins...

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Detalles Bibliográficos
Main Authors: Calabria, Andrew C., Li, Changhong, Gallagher, Paul R., Stanley, Charles A., De León, Diva D.
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2012
Assuntos:
Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447900/
https://ncbi.nlm.nih.gov/pubmed/22855730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0166
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