GLP-1 Receptor Antagonist Exendin-(9-39) Elevates Fasting Blood Glucose Levels in Congenital Hyperinsulinism Owing to Inactivating Mutations in the ATP-Sensitive K(+) Channel

Infants with congenital hyperinsulinism owing to inactivating mutations in the K(ATP) channel (K(ATP)HI) who are unresponsive to medical therapy will require pancreatectomy to control the hypoglycemia. In preclinical studies, we showed that the GLP-1 receptor antagonist exendin-(9-39) suppresses ins...

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Главные авторы: Calabria, Andrew C., Li, Changhong, Gallagher, Paul R., Stanley, Charles A., De León, Diva D.
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2012
Предметы:
Pathophysiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447900/
https://ncbi.nlm.nih.gov/pubmed/22855730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-0166
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