H1N1 2009 Pandemic Influenza Virus: Resistance of the I223R Neuraminidase Mutant Explained by Kinetic and Structural Analysis

Two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that antiviral resistant viruses emerge and spread in the human population. The 2009 pandemic H1N1 virus is already resistant to a...

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Main Authors: van der Vries, Erhard, Collins, Patrick J., Vachieri, Sebastien G., Xiong, Xiaoli, Liu, Junfeng, Walker, Philip A., Haire, Lesley F., Hay, Alan J., Schutten, Martin, Osterhaus, Albert D. M. E., Martin, Steve R., Boucher, Charles A. B., Skehel, John J., Gamblin, Steve J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447749/
https://ncbi.nlm.nih.gov/pubmed/23028314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002914
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