Multidrug Resistant 2009 A/H1N1 Influenza Clinical Isolate with a Neuraminidase I223R Mutation Retains Its Virulence and Transmissibility in Ferrets

Only two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections. A major concern is that influenza virus becomes resistant to these antiviral drugs and spreads in the human population. The 2009 pandemic A/H1N1...

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Main Authors: van der Vries, Erhard, Veldhuis Kroeze, Edwin J., Stittelaar, Koert J., Linster, Martin, Van der Linden, Anne, Schrauwen, Eefje J. A., Leijten, Lonneke M., van Amerongen, Geert, Schutten, Martin, Kuiken, Thijs, Osterhaus, Albert D. M. E., Fouchier, Ron A. M., Boucher, Charles A. B., Herfst, Sander
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3182921/
https://ncbi.nlm.nih.gov/pubmed/21980293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002276
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