Over-Expression of CYP2E1 mRNA and Protein: Implications of Xenobiotic Induced Damage in Patients with De Novo Acute Myeloid Leukemia with inv(16)(p13.1q22); CBFβ-MYH11

Environmental exposure to benzene occurs through cigarette smoke, unleaded gasoline and certain types of plastic. Benzene is converted to hematotoxic metabolites by the hepatic phase-I enzyme CYP2E1, and these metabolites are detoxified by the phase-II enzyme NQO1. The genes encoding these enzymes a...

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Hlavní autoři: Kanagal-Shamanna, Rashmi, Zhao, Weiqiang, Vadhan-Raj, Saroj, Nguyen, Martin H., Fernandez, Michael H., Medeiros, L. Jeffrey, Bueso-Ramos, Carlos E.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447587/
https://ncbi.nlm.nih.gov/pubmed/23066397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijerph9082788
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