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Toxicity in Rat Primary Neurons through the Cellular Oxidative Stress Induced by the Turn Formation at Positions 22 and 23 of Aβ42

[Image: see text] The 42-mer amyloid β-protein (Aβ42) aggregates to form soluble oligomers that cause memory loss and synaptotoxicity in Alzheimer’s disease (AD). Oxidative stress is closely related to the pathogenesis of AD. We previously identified the toxic conformer of Aβ42 with a turn at positi...

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Autors principals: Izuo, Naotaka, Kume, Toshiaki, Sato, Mizuho, Murakami, Kazuma, Irie, Kazuhiro, Izumi, Yasuhiko, Akaike, Akinori
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3447395/
https://ncbi.nlm.nih.gov/pubmed/23019494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300033k
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