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Neutralizing Antibody Escape during HIV-1 Mother-to-Child Transmission Involves Conformational Masking of Distal Epitopes in Envelope

HIV-1 variants transmitted to infants are often resistant to maternal neutralizing antibodies (NAbs), suggesting that they have escaped maternal NAb pressure. To define the molecular basis of NAb escape that contributes to selection of transmitted variants, we analyzed 5 viruses from 2 mother-to-chi...

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Autori principali: Goo, Leslie, Milligan, Caitlin, Simonich, Cassandra A., Nduati, Ruth, Overbaugh, Julie
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446598/
https://ncbi.nlm.nih.gov/pubmed/22740394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00953-12
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