A Combination of Broadly Neutralizing HIV-1 Monoclonal Antibodies Targeting Distinct Epitopes Effectively Neutralizes Variants Found in Early Infection

Neutralizing antibody protection against HIV-1 may require broad and potent antibodies targeting multiple epitopes. We tested 7 monoclonal antibodies (MAbs) against 45 viruses of diverse subtypes from early infection. The CD4 binding site MAb NIH45-46W was most broad and potent (91% coverage; geomet...

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Hauptverfasser: Goo, Leslie, Jalalian-Lechak, Zahra, Richardson, Barbra A., Overbaugh, Julie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3457273/
https://ncbi.nlm.nih.gov/pubmed/22837204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01414-12
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