Hepatitis C Virus-Mediated Inhibition of Cathepsin S Increases Invariant-Chain Expression on Hepatocyte Surface

Hepatocytes are the main source of hepatitis C virus (HCV) replication and contain the maximum viral load in an infected person. Chronic HCV infection is characterized by weak cellular immune responses to viral proteins. Cathepsin S is a lysosomal cysteine protease and controls HLA-DR–antigen comple...

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Detalhes bibliográficos
Main Authors: Kim, Hangeun, Mazumdar, Budhaditya, Bose, Sandip K., Meyer, Keith, Di Bisceglie, Adrian M., Hoft, Daniel F., Ray, Ranjit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446550/
https://ncbi.nlm.nih.gov/pubmed/22761382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00388-12
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