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Hepatitis C Virus Suppresses C9 Complement Synthesis and Impairs Membrane Attack Complex Function

Hepatitis C virus (HCV) proteins inhibit complement component expression, which may attenuate immunity against infection. In this study, we examined whether HCV regulates the membrane attack complex (MAC) via complement component C9. MAC is composed of C5b to C9 (C5b-9) and mediates cell lysis of in...

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Detalhes bibliográficos
Main Authors: Kim, Hangeun, Meyer, Keith, Di Bisceglie, Adrian M., Ray, Ranjit
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648158/
https://ncbi.nlm.nih.gov/pubmed/23487461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00174-13
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