Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.

Selective failure of lymphoid development occurs in genetic deficiency of adenosine deaminase (ADA). We examined the in vivo effects of a potent inhibitor of ADA, 2'-deoxycoformycin, which was used to treat a patient with refractory acute leukemia. Unexpectedly, within 7 days of starting treatm...

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Hlavní autoři: Hershfield, M S, Kurtzberg, J, Harden, E, Moore, J O, Whang-Peng, J, Haynes, B F
Médium: Artigo
Jazyk:Inglês
Vydáno: 1984
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC344650/
https://ncbi.nlm.nih.gov/pubmed/6607471
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