Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin.

Selective failure of lymphoid development occurs in genetic deficiency of adenosine deaminase (ADA). We examined the in vivo effects of a potent inhibitor of ADA, 2'-deoxycoformycin, which was used to treat a patient with refractory acute leukemia. Unexpectedly, within 7 days of starting treatment,...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Hershfield, M S, Kurtzberg, J, Harden, E, Moore, J O, Whang-Peng, J, Haynes, B F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1984
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC344650/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6607471/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.81.1.253
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