T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase.

Adenosine deaminase (ADA) deficiency causes severe combined immune deficiency (SCID) by interfering with the metabolism of deoxyadenosine, which is toxic to T lymphocytes at all stages of differentiation. Enzyme replacement with polyethylene glycol-modified ADA (PEG-ADA) has been previously shown to...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Weinberg, K, Hershfield, M S, Bastian, J, Kohn, D, Sender, L, Parkman, R, Lenarsky, C
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 1993
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC294890/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8349799/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116626
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