T lymphocyte ontogeny in adenosine deaminase-deficient severe combined immune deficiency after treatment with polyethylene glycol-modified adenosine deaminase.

Adenosine deaminase (ADA) deficiency causes severe combined immune deficiency (SCID) by interfering with the metabolism of deoxyadenosine, which is toxic to T lymphocytes at all stages of differentiation. Enzyme replacement with polyethylene glycol-modified ADA (PEG-ADA) has been previously shown to...

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Main Authors: Weinberg, K, Hershfield, M S, Bastian, J, Kohn, D, Sender, L, Parkman, R, Lenarsky, C
格式: Artigo
語言:Inglês
出版: 1993
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC294890/
https://ncbi.nlm.nih.gov/pubmed/8349799
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