Improving gene transfer in human renal carcinoma cells: Utilization of adenovirus vectors containing chimeric type 5 and type 35 fiber proteins

The transduction efficacy of adenovirus serotype 5 (Ad5) vector in human renal carcinoma cells is generally low due to the down-regulated expression of Coxsackie and adenovirus receptor (CAR) in target cells. By contrast, the infectivity of adenovirus serotype 35 vectors depends on the binding rate...

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Main Authors: ACHARYA, BISHNU, TERAO, SHUJI, SUZUKI, TORU, NAOE, MICHIO, HAMADA, KATSUYUKI, MIZUGUCHI, HIROYUKI, GOTOH, AKINOBU
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445923/
https://ncbi.nlm.nih.gov/pubmed/22993573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm_00000085
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