Serotonin transporter inhibition attenuates L-DOPA-induced dyskinesia without compromising L-DOPA efficacy in hemi-parkinsonian rats

Long-term dopamine replacement therapy with L-DOPA in Parkinson’s disease often leads to the development of abnormal involuntary movements known as L-DOPA-induced dyskinesia. Growing evidence suggests that following dopamine cell loss, serotonin neurons acting as surrogates for dopaminergic processe...

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Bibliographic Details
Main Authors: Bishop, Christopher, George, Jessica A., Buchta, William, Goldenberg, Adam A., Mohamed, Mohamed, Dickinson, Sando O., Eissa, Satie, Eskow Jaunarajs, Karen L.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445783/
https://ncbi.nlm.nih.gov/pubmed/22762478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1460-9568.2012.08202.x
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