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Distinct Licensing of IL-18 and IL-1β Secretion in Response to NLRP3 Inflammasome Activation
Inflammasome activation permits processing of interleukins (IL)-1β and 18 and elicits cell death (pyroptosis). Whether these responses are independently licensed or are “hard-wired” consequences of caspase-1 (casp1) activity has not been clear. Here, we show that that each of these responses is inde...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Public Library of Science
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3445464/ https://ncbi.nlm.nih.gov/pubmed/23028835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045186 |
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