A conserved Glu-Arg salt bridge connects co-evolved motifs that define the eukaryote protein kinase fold

Eukaryotic protein kinases (EPK)feature two co-evolved structural segments, the Activation segment which starts with the Asp-Phe-Gly (DFG) and ends with the Ala-Pro-Glu (APE) motifs, and the helical GHI-subdomain that comprises αG-αH-αI helices. Eukaryotic-like kinases have a much shorter Activation...

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Main Authors: Yang, Jie, Wu, Jian, Steichen, Jon M., Kornev, Alexandr P., Deal, Michael S., Li, Sheng, Sankaran, Banumathi, Woods, Virgil L., Taylor, Susan S.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3445030/
https://ncbi.nlm.nih.gov/pubmed/22138346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.11.035
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