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A conserved Glu-Arg salt bridge connects co-evolved motifs that define the eukaryote protein kinase fold
Eukaryotic protein kinases (EPK)feature two co-evolved structural segments, the Activation segment which starts with the Asp-Phe-Gly (DFG) and ends with the Ala-Pro-Glu (APE) motifs, and the helical GHI-subdomain that comprises αG-αH-αI helices. Eukaryotic-like kinases have a much shorter Activation...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3445030/ https://ncbi.nlm.nih.gov/pubmed/22138346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.11.035 |
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