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The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor
Bexarotene is an RXR-selective vitamin A analog that has been shown to prevent ER-negative mammary tumorigenesis in animal models. While investigating the mechanism by which bexarotene prevents ER-negative breast cancer development, we found that the expression of cyclin D1, a critical cell cycle pr...
Gorde:
| Egile Nagusiak: | , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444826/ https://ncbi.nlm.nih.gov/pubmed/20821348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-010-1083-9 |
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