Rexinoid-induced Expression of IGFBP-6 Requires RARβ-dependent Permissive Cooperation of Retinoid Receptors and AP-1

The synthetic rexinoid bexarotene (Targretin, LGD1069) inhibits the formation of both estrogen receptor-negative and estrogen receptor-positive breast cancer in preclinical models and controls the expression of growth-regulatory biomarkers, such as IGFBP-6 (insulin-like growth factor-binding protein...

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Autors principals: Uray, Iván P., Shen, Qiang, Seo, Hye-Sook, Kim, HeeTae, Lamph, William W., Bissonnette, Reid P., Brown, Powel H.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Transcription, Chromatin, and Epigenetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2610495/
https://ncbi.nlm.nih.gov/pubmed/18957410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804721200
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