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BMP-induced growth suppression in colon cancer cells is mediated by p21(WAF1) stabilization and modulated by RAS/ERK
Bone morphogenetic proteins (BMPs) regulate cell differentiation, proliferation, and apoptosis through a canonical SMAD signaling cascade. Absence of BMP signaling causes the formation of intestinal juvenile polyps in the colon cancer-prone syndrome familial juvenile polyposis. As sporadic colon can...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444522/ https://ncbi.nlm.nih.gov/pubmed/17317101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2007.01.017 |
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