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Regulation and physiological roles of the calpain system in muscular disorders

Calpains, a family of Ca(2+)-dependent cytosolic cysteine proteases, can modulate their substrates' structure and function through limited proteolytic activity. In the human genome, there are 15 calpain genes. The most-studied calpains, referred to as conventional calpains, are ubiquitous. Whil...

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Detalhes bibliográficos
Main Authors: Sorimachi, Hiroyuki, Ono, Yasuko
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3444232/
https://ncbi.nlm.nih.gov/pubmed/22542715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs157
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