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The role of CTCF in regulating V(D)J recombination
V(D)J recombination in B and T cells is required for the generation of receptors with a broad spectrum of specificity to foreign antigen. A total number of three immunoglobulin (Ig) and four T cell receptor (Tcr) loci can be targeted by the recombinase enzyme (RAG1/2) in a defined series of recombin...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3444155/ https://ncbi.nlm.nih.gov/pubmed/22424610 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.coi.2012.01.003 |
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