Diastolic Dysfunction and Thin Filament Dysregulation Resulting From Excitation-Contraction Uncoupling in a Mouse Model of Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) has been linked to mutations in the thin filament regulatory protein cardiac troponin I (cTnI). As the pathogenesis of RCM from genotype to clinical phenotype is not fully understood, transgenic (Tg) mice were generated with cardiac specific expression of an RCM-link...

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Detalhes bibliográficos
Main Authors: Davis, Jennifer, Yasuda, Soichiro, Palpant, Nathan, Martindale, Joshua, Stevenson, Tamara, Converso, Kimber, Metzger, Joseph M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443869/
https://ncbi.nlm.nih.gov/pubmed/22683325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.05.018
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