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Computational Design of Thermostabilizing d-Amino Acid Substitutions
Judicious incorporation of d-amino acids in engineered proteins confer many advantages such as preventing degradation by endogenous proteases, and designing novel structures and functions not accessible to homochiral polypeptides. Glycine to d-alanine substitutions at the carboxy-termini can stabili...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3443866/ https://ncbi.nlm.nih.gov/pubmed/21978298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja205609c |
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