Tyrosine Replacement of PSGL-1 Reduces Association Kinetics with P- and L-Selectin on the Cell Membrane

Binding of selectins to P-selectin glycoprotein ligand-1 (PSGL-1) mediates tethering and rolling of leukocytes on the endothelium during inflammation. Previous measurements obtained with a flow-chamber assay have shown that mutations of three tyrosines at the PSGL-1 N-terminus (Y46, Y48, and Y51) in...

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Bibliografiske detaljer
Main Authors: Xiao, Botao, Tong, Chunfang, Jia, Xiaoling, Guo, Rui, Lü, Shouqin, Zhang, Yan, McEver, Rodger P., Zhu, Cheng, Long, Mian
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2012
Fag:
Proteins and Nucleic Acids
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443791/
https://ncbi.nlm.nih.gov/pubmed/22947939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.07.028
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