The Interconversion between a Flexible β-Sheet and a Fibril β-Arrangement Constitutes the Main Conformational Event during Misfolding of PSD95-PDZ3 Domain

The temperature-induced misfolding pathway of PDZ3, the third PDZ domain of the PSD95 neuronal protein, is populated by a trimeric β-sheet-rich intermediate state that leads to a stepwise and reversible formation of supramacromolecular structures. Using FTIR, we have found that misfolding of this pa...

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Autors principals: Marin-Argany, Marta, Candel, Adela M., Murciano-Calles, Javier, Martinez, Jose C., Villegas, Sandra
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2012
Matèries:
Proteins and Nucleic Acids
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443772/
https://ncbi.nlm.nih.gov/pubmed/22947935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.07.029
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