The Interconversion between a Flexible β-Sheet and a Fibril β-Arrangement Constitutes the Main Conformational Event during Misfolding of PSD95-PDZ3 Domain

The temperature-induced misfolding pathway of PDZ3, the third PDZ domain of the PSD95 neuronal protein, is populated by a trimeric β-sheet-rich intermediate state that leads to a stepwise and reversible formation of supramacromolecular structures. Using FTIR, we have found that misfolding of this pa...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Marin-Argany, Marta, Candel, Adela M., Murciano-Calles, Javier, Martinez, Jose C., Villegas, Sandra
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2012
Materias:
Proteins and Nucleic Acids
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443772/
https://ncbi.nlm.nih.gov/pubmed/22947935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.07.029
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares