Quantitative analysis of thrombomodulin-mediated conversion of Protein C to APC: translation from in vitro to in vivo

Thrombomodulin-bound thrombin cleaves protein C (PC) zymogen in blood plasma producing activated protein C (APC), which exerts anti-coagulant, anti-inflammatory, anti-apoptotic and CNS-protective effects. Recombinant APC and thrombomodulin (TM) are both in clinical studies for management of acute co...

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Main Authors: Carnemolla, Ronald, Patel, Kruti Rajan, Zaitsev, Sergei, Cines, Douglas B., Esmon, Charles T., Muzykantov, Vladimir R.
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3443618/
https://ncbi.nlm.nih.gov/pubmed/22750541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jim.2012.06.012
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